MirGeneDB 3.0
MirGeneDB ID

Dre-Let-7-P2a1a

Family name LET-7 (all species)
Species Zebrafish (Danio rerio)
MiRBase ID dre-let-7a-1
Paralogues Dre-Let-7-P1b1  Dre-Let-7-P1b2  Dre-Let-7-P1c1  Dre-Let-7-P1c2  Dre-Let-7-P1d1  Dre-Let-7-P1d2  Dre-Let-7-P2a2a  Dre-Let-7-P2a2b  Dre-Let-7-P2a3a  Dre-Let-7-P2a3b  Dre-Let-7-P2a4a  Dre-Let-7-P2a4b  Dre-Let-7-P2b1a  Dre-Let-7-P2b2a  Dre-Let-7-P2b2b  Dre-Let-7-P2b3a  Dre-Let-7-P2b4a  Dre-Let-7-P2b4b  Dre-Let-7-P2c2b  Dre-Let-7-P2c3 
Orthologues Aae-Let-7  Aca-Let-7-P2a1  Aga-Let-7  Agr-Let-7  Ami-Let-7-P2a1  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Bta-Let-7-P2a1  Cfa-Let-7-P2a1  Cja-Let-7-P2a1  Cli-Let-7-P2a1  Cmi-Let-7-P2a1  Cpi-Let-7-P2a1  Cpo-Let-7-P2a1  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dno-Let-7-P2a1  Dpu-Let-7  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Eca-Let-7-P2a1  Egr-Let-7  Esc-Let-7  Ete-Let-7-P2a1  Gga-Let-7-P2a1  Gja-Let-7-P2a1  Gmo-Let-7-P2a1a  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Hsa-Let-7-P2a1  Isc-Let-7  Laf-Let-7-P2a1  Lan-Let-7  Lch-Let-7-P2a1  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Loc-Let-7-P2a1  Mal-Let-7-P2a1a  Mdo-Let-7-P2a1  Mgi-Let-7  Mml-Let-7-P2a1  Mmr-Let-7-P2a1  Mmu-Let-7-P2a1  Mom-Let-7  Mun-Let-7-P2a1  Npo-Let-7  Oan-Let-7-P2a1  Obi-Let-7  Ocu-Let-7-P2a1  Ofu-Let-7  Ovu-Let-7  Pab-Let-7-P2a1  Pau-Let-7  Pbv-Let-7-P2a1  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rno-Let-7-P2a1  Rph-Let-7  Sha-Let-7-P2a1  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spt-Let-7-P2a1  Spu-Let-7  Sro-Let-7  Sto-Let-7-P2a1  Tca-Let-7  Tgu-Let-7-P2a1  Tur-Let-7  War-Let-7  Xbo-Let-7  Xla-Let-7-P2a1c  Xla-Let-7-P2a1d  Xtr-Let-7-P2a1 
Node of Origin (locus) Clupeocephala
Node of Origin (family) Bilateria
Genome context
(danRer11)		 chr11: 27503240-27503310 [-] UCSC Ensembl
Clustered miRNAs
(< 50kb from Let-7-P2a1a)		 Let-7-P2b1a chr11: 27503037-27503113 [-] UCSC Ensembl
Let-7-P2a1a chr11: 27503240-27503310 [-] UCSC Ensembl
Seed GAGGUAG
Precursor
(pre-Mir +30nt flank)		 
UGGACUGGAGGUUACAUGUUGACGGUGGGAUGAGGUAGUAGGUUGUAUAGUUUUAGGGUCACACCCACACUGGGAGAUAACUAUACAACCUACUGUCUUUCUCAAAGUCCAAAUCAAGCUACAGAGUUUCA
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Structure
        10        20          30        40        50        60     
UGGACUGGAGGUUACAUGUU--|  GG     U   GU                UUAGGGUCACAC 
                      GAC  UGGGA GAG  AGUAGGUUGUAUAGUU            C
                      CUG  ACUCU UUC  UCAUCCAACAUAUCAA            C
ACUUUGAGACAUCGAACUAAAC^  AA     -   UG                UAGAGGGUCACA 
 .       120       110       100         90        80        70
Deep sequencing
CommentAlthough there is a templated T at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' U is supported by the CAGE data from de Rie et al. (2017).
3' NTU Yes
MotifsUG at 5p(-14), CNNC at 3p(+17)
Tissue expression
- +
Br Br Em Ey Gu Gu He Li Li Ov Te
Mature sequence

Dre-Let-7-P2a1a_5p
mirBase accessionMIMAT0001759
Sequence 
0- UGAGGUAGUAGGUUGUAUAGUU -22
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Proposed targets TargetScanFish: dre-let-7a
Star sequence

Dre-Let-7-P2a1a_3p*
mirBase accessionNone
Sequence 
50- CUAUACAACCUACUGUCUUUC -71
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